Celiac sprue, also known simply as celiac disease, is an autoimmune disorder where the body's immune system mistakenly reacts to gluten, a protein found in wheat, barley, and rye. This reaction causes inflammation and damage to the lining of the small intestine, specifically to tiny hair-like structures called villi, which are responsible for nutrient absorption. Over time, this damage prevents the body from absorbing essential nutrients properly, leading to a wide range of symptoms like diarrhea, weight loss, and fatigue. Celiac sprue is a lifelong condition that requires strict management through a gluten-free diet to avoid complications.
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